Relation of Antioxidant Native Thiol Level with Inflammatory Markers and Disease Activity Index in Pediatric Ulcerative Colitis

Objective: Pediatric ulcerative colitis (PUC) is an inflammatory disease. PUC pathogenesis associated with imbalance between reactive oxygen species and antioxidant activity which creates oxidative stress. Native thiol (NT) level capacity practical repeatable marker of inflammation antioxidan level. We aimed to analyse the relation NT markers pediatric index (PUCAI). Material Methods: Thirty-eight patients (SG) 33 control group (CG) participants were included in study. grouped as remission, mild, moderate severe according disease PUCAI. NT, hemoglobin (Hb), white blood cell (WBC), platelet (PLT), mean volume (MPV), albumin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 6 (IL-6) levels all measured at time they enrolled study recorded. Results: Mean age gender ratio groups similar (p>0.050). SG statistically high compared CG (p=0.001). Hb, PLT, MPV, CRP, ESR, IL-6 different than (p=0.045, p=0.026, p=0.001, p=0.001). was positively correlated albumin (p=0.001, for all). negatively PUCAI Conclusion: significantly lower CG. a good prognostic factor patients. may be repeatable, noninvasive candidate serum biomarker management.